A reverse phase high performance liquid chromatography (RP-HPLC) method for the simultaneous estimation of Metoprolol succinate (MS) and Olmeartan medoxomil (OM) in marketed formulation is developed. The determination was carried out on a Hibar 250-4.6 RP18 (5um) column using a mobile phase of Methanol: Water: Acetonitrile (70:20:10) pH-3.4 with ortho phosphoric acid. The flow rate was 1.0 ml/min with detection at 231 nm.The retention time for Metoprolol succinate 2.1 min and Olmeartan medoxomil 3.0 min. Metoprolol succinate and Olmeartan medoxomil showed a linear response in the concentration range of 5-30µg/ml and 2-12 µg/ml respectively. The correlation co-efficient (r2) 0.997 for Metoprolol succinate and 0.999 for Omesartan medoxomil.The results of analysis have been validated statistically and by recovery studies.The percentage recoveries obtained for Metoprolol succinate and Omesartan medoxomil ranges from 99.05-101.28%.
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